Research library / Comparisons

vs : what is the difference?

Two seven-residue peptides with the same tail and different parents.

and are both synthetic seven-amino-acid peptides from the same Russian research tradition, and both end in the tripeptide Pro–Gly–Pro. They extend different natural peptides, though, and their research literatures point in different directions. Here is how they compare.

Prism Labs editorial · Updated September 10, 2026 · 3 min read

Lyophilized vial5mg · 10mg · 99.71% purity$35.99View product

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At a glance

The main differences in one list:

Parent peptide: extends ACTH(4–7), a fragment of adrenocorticotropic hormone; extends tuftsin, a four-residue immune peptide.
Sequence: MEHFPGP for ; TKPRPGP for .
Reference formula: C37H51N9O10S (813.9 g/mol) versus C33H57N11O9 (751.9 g/mol).
Research focus: neurotrophic gene expression such as BDNF for ; stress-response and GABA-related gene expression for .
Formats at Prism Labs: both as 5 mg or 10 mg vials and as a premixed 10 mg nasal spray.

Sources: [1] PubChem · reference structure · [2] PubChem · reference structure · [5] Brain Research · 2006 · [6] Frontiers in Pharmacology · 2016

Lyophilized vial from Prism Labs — Both products, each documented lot by lot.

What they share

Both were developed in the same Moscow research tradition, which studied short regulatory peptides and the Pro–Gly–Pro motif its researchers called glyprolines. Both are seven residues long and small enough to identify by mass spectrometry.

Modified variants of both are sold, such as N-acetylated forms, so check that the formula on the COA matches the unmodified sequence you ordered.

Sources: [3] Russian Journal of Physiology · 2001 · [4] Current Medicinal Chemistry · 2017

Different parents: ACTH and tuftsin

begins with ACTH(4–7), a stretch of the pituitary hormone that regulates the adrenal glands. Its literature grew out of research on short ACTH fragments.

begins with tuftsin, Thr–Lys–Pro–Arg, a peptide first described as a fragment of an antibody heavy chain. Its literature starts in immunology and stress research.

Sources: [3] Russian Journal of Physiology · 2001 · [4] Current Medicinal Chemistry · 2017

How their research differs

Most studies of both are in rodents and cell cultures, and most measure gene expression:

: BDNF, NGF and their receptors in rat brain tissue.
: inflammation-related genes over time, and genes involved in GABA signaling.
Both: a 2020 study examined them in the same brain-network experiments.

These are observations in laboratory models. They are not evidence about any use in people.

Sources: [5] Brain Research · 2006 · [6] Frontiers in Pharmacology · 2016 · [7] Doklady Biological Sciences · 2020

Formats and full profiles

Prism Labs offers each as a lyophilized vial (5 mg or 10 mg) and as a premixed 10 mg nasal spray in a 10 mL bottle, about 100 sprays. Each format has its own lot and COA. How the formats differ: peptide nasal spray vs vial.

Full profiles: What is peptide? and What is peptide?

A little more clarity

Questions, answered

What is the difference between and ?

Both are seven-residue synthetic peptides ending in Pro–Gly–Pro. One extends an ACTH fragment (MEHFPGP), the other tuftsin (TKPRPGP), and their research literatures differ.

Are and the same?

No. They share a three-residue tail but have different sequences, parent peptides and formulas.

Were they developed by the same group?

They come from the same Moscow research tradition on short regulatory peptides and the Pro–Gly–Pro motif.

Do both come as a nasal spray?

Yes. Prism Labs offers each as a premixed 10 mg nasal spray and as 5 mg or 10 mg vials, each with its own COA.

Are they for human use?

No. Prism Labs sells both for laboratory research use only.

Follow the evidence

Sources & reading notes

Open the original record for its methods and limitations. The sources below do not certify the supplied product or its finished formulation.

PubChem · reference structure ↗
Reference structure of the ACTH-fragment analogue; not a batch measurement.
PubChem · reference structure ↗
Reference structure of the tuftsin analogue; not a batch measurement.
Russian Journal of Physiology · 2001 ↗
Review of ACTH-fragment and glyproline peptides by the originating group.
Current Medicinal Chemistry · 2017 ↗
Review of tuftsin and its analogues.
Brain Research · 2006 ↗
BDNF and TrkB expression in the rat hippocampus.
Frontiers in Pharmacology · 2016 ↗
Genes involved in GABA signaling.
Doklady Biological Sciences · 2020 ↗
Brain-network study of both seven-residue peptides.

Prepared by Prism Labs from the linked source records and public product documentation. Research context only; not a preparation protocol or a claim about outcomes. Send a source correction.

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